Gameplay
- New Game Aspects
- Enemies
- Little Sisters
- Little Brothers
- Splicers
- Armored Enemies
- Updated
- New
- Slicer
- Golem
- Blaster
- Hawkeye
- Delta Series
- Security
- Updated
- New
- Trip Beam
- Cyber Splicer Alarm
- Little Sisters
- Weapons
- Plasmids
- Updated
- Electro-Bolt
- Incinerate!
- Winter Blast
- Insect Swarm
- Gravity Well
- Telekinesis
- Scout
- Decoy
- Hypnotize
- Security Command
- Cyclone Trap
- New
- Corruption
- Flash
- Dash
- Spout
- Houdini
- Blast Core
- Push
- Spider Plasmid
- Updated
- Gene Tonics
- Items
- Vehicles
- Returning
- Atlantic Express
- Bathysphere
- stairs
- Skyline
- Tears
- New
- Cargo Ship
- Zeppelin
- Supply Train
- Returning
Story