Walk to the left side of the upper level and place a Target Dummy in front of each of the Machine Gun Turrets opposite; the RPG Turrets overhead will destroy them.
Place another Target Dummy by the left-hand door on the opposite platform to draw the RPG fire.
Head down the stairs to the left and walk carefully along the narrow beam to the right. When at the far-right wall, turn left and cross to the opposite side of the room with the destroyed Turrets.
Head towards the open door, placing more Target Dummies to draw the RPG fire.
Go through the door to find an Inventing Supplies crate containing a Battery.
Head through the glass tunnel and pick up the First Aid Kit on the floor; enter the Pressure Plate Room.
Pressure Plate Room
There's a First Aid Kit and four EVE Hypos on the pressure plate in the middle of the room.
Use a Target Dummy to lure the Bouncer onto the plate; this will open the opposite door.
Head through the door as soon as it opens.
There's a First Aid Kit and three EVE Hypos on top of the desk.
Now proceed through the door to the Firing Range and use the tool to hack the Right Side Door Control switch.
The Little Sister's Bouncer will enter the Firing Range and run back and forth along it.
Place Target Dummies anywhere along the Bouncer's path to start the RPG Turrets firing; use Winter Blast 3 to freeze the Bouncer if he keeps dodging the RPGs.
When the Bouncer is dead, place a Target Dummy to draw the RPG fire and go and rescue the Little Sister; press Triangle to "collect" her.
This Trophy requires the player to rescue the Little Sister without destroying any of the Turrets in the stage: make extensive use of the Target DummyPlasmid to draw all of the Turret fire during your first journey through the Firing Range.
This Trophy requires the player only to find the four Roses hidden throughout the stage. Their locations are:
On the desk in the Reception.
Hanging from the ceiling in the Machine Room; once one has Winter Blast 3 lure the Bouncer close to one of the elevated areas, freeze him, and jump on top of him. From here, the player should be able to reach the Rose if they jump.
Inside the central RPG Turret; once the Bouncer guarding the Little Sister is dead, search his corpse for a Grenade Launcher and ten Frag Grenades. Destroy the middle RPG Turret and knock it down to the ground, where the player can search it for the third Rose.
Behind a secret door in the Machine Room; it opens when the Bouncer in the Pressure Plate Room stands on the pressure plate. Lure him onto the plate using Target Dummy and run towards the Machine Room as quickly as possible. Grab the Rose before the Bouncer can move off the plate.
Like all of the Challenge Rooms, the Little Sister the player must save appears to have already been "rescued", as she bears none of the signs of being implanted with a Sea Slug.
When collecting the Rose from the RPG Turret in the PlayStation 3 version of the content, an image icon of a Rose will appear in the Turret's inventory. However, in the Xbox 360 version, the image icon will be an Apple, as seen from the EVE Upgrade slot.
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