Tenenbaum's Safe House

• Weapons and Plasmids are disabled, but the player can pick things up.
• A First Aid Kit ("FAK") is right beside Jack.
• Snacks are laying around the area.
• There's an EVE Hypo to the left when walking through the downstairs area.
• A crate is on the other side.
• Some cash is on one of the bunks.
• Don't go upstairs until a Little Sister says: "Come with me."
• Upstairs: a lockbox with components is in a corner.
• Follow the Little Sister to find a door leading to...

Olympus Heights Sewers

• Cross the sewer and walk along the wall to a crate with cash.
• Cross over at the end and pick up the Gate Crank.
• An Automatic Hack Tool is in a lockbox. Coffee, Potato Chips, and a lockbox are nearby.
• Walk back to the Gate Crank Socket and do the obvious.
• Fontaine says Jack's health capacity will be reduced little by little.
• Hopefully, the player has been buying all the Health Upgrades as they went.
• Whatever one starts with, it will never completely run out.
• Go up the ramp to arrive in...

Street #1

• Splicers are going to be a lot tougher in Olympus Heights.
• Turn right, walk to the street, look left for a Frag on the ground.
• Before one rushes to get it, look left further down for two Splicers.
• Incendiary Bolts are a good choice. Be sure to zoom in.
• Walk down to them and do the usual looting.
• Go left to the fire and look right.
• Safe: Very Hard. 4 Electric Buck, 98 Napalm, 2 FAKs.
• If the player left the Automatic Hack Tool in the lockbox, use one on the safe and go back for it.
• A Big Daddy and Little Sister will come by. Take photos, but don't kill.
• Easier prey lies ahead.

Building #1

• Enter the door on the right and run straight to the wall.
• A Turret is inside. Hack it.
• A Security Camera is off to the right, so back out the way one came.
• Enter from the right, stop, look over at the Camera.
• Wait for a Nitro Splicer to appear near the device.
• Hit him with an Incendiary Bolt and move to the left of the front area.
• The Splicer should come after Jack if the shot didn't kill him.
• When the hacked Turret starts firing, come back out and help.
• Go back in and hack the Security Camera and the Health Station.
• Go through the left side of the bar; pick up cash, Audio Diary: Mozart Of Genetics.
• At the edge of the next doorway, set a Target Dummy down the hall.
• When the Turret starts firing, run out and hack it.
• Run back into the bar until things settle down.
• An El Ammo Bandito (Very Hard) has 3 Proximity Mines.
• Exit the bar by the Security Camera and continue to the left.
• A Circus of Values ("CoV"): Very Hard. Proxy Mines and Automatic Hack Tools.
• Kill the Rosie.
• Visit the Gatherer's Garden.
  • Great stuff: Health Upgrade, Incinerate! 3, Hacking Expert 2, Electro Bolt 3.
  • If the player has been investing wisely, it will be possible to purchase all of these.
• Follow the arrow to...

Street #2

• A "corpse" is against a pole in the middle.
• Use Telekinesis ("TK") to fetch his body.
• When it doesn't come, zoom in and put an I-Bolt to his head.
• Advance to the pole to loot him. Something blinks further down right.
• Use TK to fetch a Crossbow (4 Bolts).
• Something blinks way down left. Fetch the Electric Buck.
• There are more things to fetch in this area, such as more Electric Buck.
• A railway carriage on the left with EVE, Liquid Nitrogen, cash and snacks.
• Continue down to the U-Invent.
• Get Target Dummy ready because tough Splicers await at the entry to...

Mercury Suites

• A Security Camera (Medium) is to the left of the entry.
• A BD and LS will appear when one enters. Kill it.
• If the player wanted anything they couldn't afford at the last Gatherer's Garden, now is the time to return to get it. Soon it won't be possible until after a very long time.
• Hack the Security Camera.
• Around the corner is a Power to the People station with Napalm in front of it.
• Further in front of it is a corpse with a Grenade Launcher (1 Frag).
• Facing the back wall, go to the left to...

• Suchong's Apartment:
  • Room to left: Leadhead behind sandbags. Recording: Fontaine's Human Jukebox.
  • Room to right: Thuggish, corpses with cash.
  • Flooded room: Recording: Mind Control Antidote, Clever Inventor, crates.
  • Try to exit the apartment and an RPG Turret to the right will shoot at Jack.
  • To hack it without losing health:
    • Approach the door from the right until it opens.
    • Set a Target Dummy in the doorway and bring up a weapon.
    • Time an exit for the right after an RPG whizzes through.
    • Run straight out to the left side of the wall ahead.
    • A Splicer will be around somewhere. Kill him.
    • Turn around and put another Target Dummy by Suchong's door.
    • Run around the left side of the wall and hack the Turret.

• Anna Culpepper's Apartment:
  • A Security Camera is in a hall to the left.
  • After hacking it, run to the other side of the room and
  • put a Target Dummy in front of it for the 2 Splicers.
  • In the room is a recording: Artist Woman.
  • Go to the right of the camera and loot.
  • Don't miss the FAK up in a cabinet.
  • Upstairs in a flooded room: EVE and a FAK on sofa.
  • Steamer trunk has components. Corpse in tub has ~$32.
  • Exit apartment and head left to ...

• Cohen's Apartment:
  • If the player didn't kill Cohen at Fort Frolic, now's their chance.
  • Room to the left: Splicer playing dead, Liquid Nitrogen, Napalm.
  • Room to the right is a kitchen. Some food, Coffee.
  • Door to the right is locked. Cohen is upstairs.
  • If one hasn't yet killed Cohen:
    • Set up two or three Proxy Mines right onto the door.
    • Put the rest of the Proximity Mines on the steps down to the dance room.
    • Move to the room to the right and Napalm the dancers.
    • Move back into the corner and wait.
    • When Cohen's blown up, take a picture of him (PS3 and Xbox360 only).
    • His corpse has good loot, including his key.
    • Go upstairs and loot: 2 Frags, ammo, 2 FAKs in bathroom.
    • Visit the Power To The People station.
  • Downstairs: Electric Buck, FAK, ammo.
  • Exit and go...

• Up The Ramp:
  • Get off at the 2nd floor and turn left.
  • A Nitro Splicer is coming from the left walkway.
  • The most efficient way to kill him is to run up close to him.
  • From point blank range, start shooting Antipersonnel Auto Rounds.
  • About a dozen rounds will do him in.
• Apartment On Opposite Side:
  • A family is dead in the living room, with a bottle of poison on the table. EVE on the desk to the left.
  • A lone Thuggish Splicer can be encountered in the room beyond the arches.
  • Behind a bed in back is a safe: Hard, ammo, $68, 2 Brass Tubes.
  • Bathroom (trapped): EVE, Film, FAK.
• Ramp Up To 3rd Floor:
  • A fixed Security Camera detects Jack when the player reaches the 3rd floor.
  • Liquid Nitrogen will freeze it. Run up to it and hack it while it's frozen.
  • Turn right and go to end of hall: 2 Frags and ammo in a hole in the wall.
  • Continue down the hall.
• Unmarked apartment has very little besides three tough Splicers. Skip it or save it for later.
• "Corpse" on the floor just past the apartment is not dead. Rectify that with an I-Bolt.
• Continue to a U-Invent and on to some Film, recording: Fontaine's Breakup.
• This recording has the code to Fontaine's elevator's lock.
• Continue to a large hole in wall, which is...

• Tenenbaum's Apartment:
  • Health Station, EVE, FAK to the right.
  • Go through two rooms, turn right, past some stairs to a room with a Splicer.
  • Room has cash, EVE, Proximity Mine, FAK up high.
  • Go back and down the stairs to a series of flooded rooms.
  • Room to the right of the door has a Machine Gun Turret in the back.
  • Safe: Very Hard, 2 Alcohol, $55, 6 Incendiary Bolts.
  • Door has a lock on it. Leadhead Splicer waits on the other side.
    • Stay in the room with the hacked Turret, in the corner left of the doorway.
    • Shoot the lock. She will come in looking for Jack.
    • If the player has Natural Camouflage, all she'll see is the Turret.
• Go back to first floor and the elevator to ...

• Fontaine's Penthouse:
  • Code to elevator: 5744 (from earlier recording).
  • The trip to the penthouse door is very tricky.
  • Here is one possible strategy:
    • Stay in the elevator until one sees a Splicer to the right walking away.
    • Get Crossbow ready with I-Bolts.
    • Get out, move to the left walkway, and back up into a nook.
    • Look right and note the Bot Shutdown Panel.
    • The player should only need it if they don't have Target Dummy.
    • Wait for a Splicer to show up at the far end of the walkway.
    • Zoom in for a headshot and kill him when he's close enough.
    • Inch over to the left until one sees a Splicer at the far end.
    • A middle shot will kill him without hurting the Turret.
    • Move back to the elevator and walk to the big rock.
    • Set a Target Dummy out to the right for the Turret and the Security Camera.
    • Move around the left side of rock, hack the Turret, run to the wall left of the door.
    • Watch for a Splicer and help the Turret kill her.
    • Hack the Security Camera.

• Go inside to the room on the right. Recording: Sad Saps.
• Go up the stairs on the left, through the bedroom to the study.
• Go out the other door, cross the walkway, get out Electro Bolt.
• A Turret is behind the bar to the right.
• The player'll have to zap it and run around the bar to hack it.
• Safe: Very Hard. Liquid Nitrogen, 2 EVE Hypo, about $37.
• Go back to the study: Electric Flesh 2, Napalm, Lot 192.
• Go back downstairs. Watch for Splicers (may be none on Medium and Easy).
• As soon as the front door opens, a Nitro Splicer attacks.
• Since one cannot rely on Telekinesis anymore, have Frags ready.
• Keep firing Grenades and backing up until everyone's dead.
• Alternatively, set Proxy Mines and Trap Bolta before going in.
• A Splicer-Bot pair will be at the far end by the elevator.
• Easiest kill is to shoot a Trap Bolt in his path.
• Loot all around (just in case) and take the elevator back down.
• Wait for any excitement to die down, loot all around the room.
• Follow the arrow back out to Street #2 and back to...

Building #1

• Splicers are around, including a Nitro, but can be avoided.
• A CoV machine is to the left when one enters.
• Keep going left to the bulkhead to Apollo Square.