"There is something more powerful than each of us, a combination of our efforts, a Great Chain of industry that unites us. But it is only when we struggle in our own interest that the chain pulls society in the right direction..." - Andrew Ryan
- "The Little Sister's Orphanage: In troubled times, give your little girl the life that she deserves. Boarding and education free of charge! After all, children ARE the future of Rapture."
- ―Public address advertisement[src]
The Little Sister's Orphanage is a home for the Little Sisters in Rapture, founded by Frank Fontaine and located in several areas of the city, including Hestia and Plaza Hedone. Fontaine used the Orphanage as a front to gather little girls for the transformation into biological ADAM producing factories. It is more than likely that the term "Little Sisters" originally came from the Orphanage's name. Public address announcements advertised that the poorer citizens of Rapture should put their children in the Orphanage with the promise of their safety, education, and bright future. Such broadcasts are obviously dated, as Andrew Ryan began to forcibly take the children after parents started catching on to what the Orphanage was really for.