Little Sister's Orphanage

From BioShock Wiki

"The Little Sisters Orphanage: In troubled times, give your little girl the life that she deserves. Boarding and education free of charge! After all, children ARE the future of Rapture."

―Advertisement for Little Sisters Orphanage^[src]

The Little Sister's Orphanage is a home for the Little Sisters in Rapture, founded by Frank Fontaine and located in Hestia. Fontaine used the Orphanage as a front to gather little girls for the transformation into biological ADAM producing factories. It is more than likely that the term "Little Sisters" originaly came from the Orphanage's name. Public Address Announcements are often heard advertising that the poorer citizens of Rapture should put their children in the Orphanage with the promise of their safety, education, and bright future. Such broadcasts are obviously dated, as Andrew Ryan began to forcibly take the children after parents began catching on to what the Orphanage was really for.