Bridgette Tenenbaum
From BioShock Wiki
Dr. Bridgette Tenenbaum is a German genetic scientist who helped originally develop ADAM. She is also the "mother" of the Little Sisters. She created them and cares a great deal about their safety. You are able to win her allegiance by saving the Little Sisters instead of harvesting them for ADAM.
It is implied that she is either Jewish or (more likely) is of Jewish ancestry due to her surname and the conditions she was held under.
Tenenbaum managed to survive being held prisoner in WW2 where she discovered she had a love for science. The Germans picked up on this and she was a doctor for them at the age of 16. Tenenbaum would notice that what some of the doctors were doing was wrong and correct them. She was a scientific genius at a very young age.
Tenenbaum was the first to discover ADAM. Tenenbaum discovered a slug that changes the body and the mind giving the user many powers. At first she was snubbed by the scientists of Rapture but with the help of Frank Fontaine she was able to get her invention off the ground and quickly became one of the most well known women in Rapture.
With Fontaine's help she was able to create the Little Sisters, but once she realised what she was doing she became disgusted with herself. Realising that she was simply creating monsters, Tenenbaum began to hate herself for what she had done. By the time Jack arrives in Rapture she has seen the error of her ways and begs Jack to help the Little Sisters. If Jack does what she asks he only retrieves 80 ADAM per rescue, but after every three rescues she rewards him with 200 ADAM and various other items including rare Plasmids. If Jack chooses to harvest the Little Sisters, he retrieves 160 ADAM, and she does nothing but express her anger towards him. Jack's choice is left to the player.
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Towards the conclusion of the game, Tenenbaum helps Jack by removing Fontaine's mental conditioning and showing him what he really is, becoming his only and true ally. She frees him and lets him live a real life. In the ending of the game where Jack raises the Little Sisters, it is likely that Tenenbaum either came to the surface with Jack and continued to be a motherly figure, or with Ryan, Fontaine, and most Splicers dead, she stayed behind to look for Little Sisters to exorcise and/or protect.
